Klotho

Klotho upsc notes
  Origin
    Nature
  Context
    New study
      Injection of 'longevity factor' protein
        In ageing monkeys
        Restoration of Klotho levels
        Improvement in cognitive function
  Explanation
    Klotho
      An enzyme
      Encoded by KL gene
      Produced in kidney
    Soluble Klotho levels
      Decrease with age
    Klotho gene association
      Increased risk of age-related diseases
  Significance of findings
    Potential new treatments
      For neurodegenerative diseases
  Previous research
    On mice
    Observations
      Klotho injections extended life
      Increased synaptic plasticity
        Capacity to control communication
          Between neurons
          At junctions termed synapses

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