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Klotho

Klotho upsc notes
Origin
Nature
Context
New study
Injection of 'longevity factor' protein
In ageing monkeys
Restoration of Klotho levels
Improvement in cognitive function
Explanation
Klotho
An enzyme
Encoded by KL gene
Produced in kidney
Soluble Klotho levels
Decrease with age
Klotho gene association
Increased risk of age-related diseases
Significance of findings
Potential new treatments
For neurodegenerative diseases
Previous research
On mice
Observations
Klotho injections extended life
Increased synaptic plasticity
Capacity to control communication
Between neurons
At junctions termed synapses

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