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Amyloidosis

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Santhosh Kumar 23/11/2023
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Amyloidosis mind map COntext Scientists from Institute of Advanced Study in Science and Technology, Guwahati (IASST) Under Department of Science and Technology (DST) in North-East India Successfully fabricated 2D protein monolayer Using lysozyme molecules Lysozyme Crucial protein in mucosal secretions Principal component of airway fluid Model protein for understanding diseases like Amyloidosis Understanding Amyloidosis: A Rare Disease with Multi-Organ Impact Amyloidosis characterized by accumulation of amyloid in organs Adversely affects functioning of vital organs Heart, kidneys, liver, spleen, nervous system, digestive tract Leads to multi-organ dysfunction Lysozyme as a Model Protein in Disease Study Lysozyme’s role in studying Amyloidosis Misfolding and agglomeration of lysozyme molecules Implicated in development of Amyloidosis Valuable subject for scientific inquiry Innovative Fabrication of 2D Protein Monolayer Led by Dr. Sarathi Kundu, Associate Professor at IASST Collaboration with junior Research Fellow Himadri Nath Fabrication of 2D protein monolayer Assembling lysozyme molecules at air-water and air-solid interfaces Employed Langmuir-Blodgett (LB) technique Insights into Lysozyme Behavior Study published in RSC Advances under RSC publishers Explored physical properties of lysozyme molecules Compressible behavior of lysozyme monolayers Formation of stripe-like domains with increasing surface pressure Investigated under varying subphase pH conditions Provided insights into structural, conformational changes of lysozyme molecules Applications and Future Implications Closely packed lysozyme monolayers Exciting avenue for studying chemical, physical properties in 2D protein environment Deposited LB films of lysozyme Potential as protein nanotemplates Opportunities for crystallization of proteins of interest

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