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Amyloidosis

Amyloidosis mind map
COntext
Scientists from Institute of Advanced Study in Science and Technology, Guwahati (IASST)
Under Department of Science and Technology (DST) in North-East India
Successfully fabricated 2D protein monolayer
Using lysozyme molecules
Lysozyme
Crucial protein in mucosal secretions
Principal component of airway fluid
Model protein for understanding diseases like Amyloidosis
Understanding Amyloidosis: A Rare Disease with Multi-Organ Impact
Amyloidosis characterized by accumulation of amyloid in organs
Adversely affects functioning of vital organs
Heart, kidneys, liver, spleen, nervous system, digestive tract
Leads to multi-organ dysfunction
Lysozyme as a Model Protein in Disease Study
Lysozyme’s role in studying Amyloidosis
Misfolding and agglomeration of lysozyme molecules
Implicated in development of Amyloidosis
Valuable subject for scientific inquiry
Innovative Fabrication of 2D Protein Monolayer
Led by Dr. Sarathi Kundu, Associate Professor at IASST
Collaboration with junior Research Fellow Himadri Nath
Fabrication of 2D protein monolayer
Assembling lysozyme molecules at air-water and air-solid interfaces
Employed Langmuir-Blodgett (LB) technique
Insights into Lysozyme Behavior
Study published in RSC Advances under RSC publishers
Explored physical properties of lysozyme molecules
Compressible behavior of lysozyme monolayers
Formation of stripe-like domains with increasing surface pressure
Investigated under varying subphase pH conditions
Provided insights into structural, conformational changes of lysozyme molecules
Applications and Future Implications
Closely packed lysozyme monolayers
Exciting avenue for studying chemical, physical properties in 2D protein environment
Deposited LB films of lysozyme
Potential as protein nanotemplates
Opportunities for crystallization of proteins of interest

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