Landmark Paper Sparks Decades of AIDS Research

Dr. Michael Gottlieb’s 1981 research on pneumocystis pneumonia led to the first identification of AIDS. Despite 50 years of study, HIV’s high genetic diversity and error-prone replication hinder vaccine development. B-cells play a crucial role in immunity by producing antibodies. Advances in germline targeting and nanoparticle-based vaccines show promise. HIV-1 is the most widespread type, with significant genetic variability affecting treatment and diagnostics.

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