Kill switch

Kill switch mind map
Discovery
By UC Davis Comprehensive Cancer Center
Key findings
Published
In journal Cell Death & Differentiation
Identified element
Crucial epitope on CD95 receptor
A protein section
Can activate the larger protein
Causes cell death
Target
Programmed cell death
Triggered by epitope on CD95
Implications
Cancer treatment
Opening doors for improved therapies
Tumor cells
Termination potential
Enhancement of immunotherapies
Significance
Potential one-two punch against tumors
Revolutionary
In cancer treatment approach
Self-destruction
Of cancer cells programmed
Research context
Ongoing battle against cancer
New weapon
In form of identified protein

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$93% DPT3 immunisation coverage in 2022: WHO upsc notes Source: TH According to World Health Organization (WHO) India’s coverage rate For the DPT3 vaccine Diphtheria, pertussis, and tetanus Reached an all-time high Of 93% in 2022 Surpassed the pre-pandemic best Of 91% in 2019 Showed a significant increase From 85% recorded in 2021 In the WHO South-East Asia Region The DPT3 coverage rate Recovered to pre-pandemic levels At 91% in 2022 Up from 82% in 2021 Key Findings The region witnessed improvements In the coverage of the measles vaccine Which rose to 92% in 2022 From 86% in 2021 The number of zero-dose children Halved to 2.3 million in 2022 From 4.6 million in 2021 Number of partially vaccinated children Decreased to 650,000 in 2022 From 1.3 million in 2021 India and Indonesia Credited for the region’s strong immunization recoveries They made significant efforts To improve vaccination rates The report highlighted the importance Of closing gaps in immunization coverage At the subnational level To prevent outbreaks Of vaccine-preventable diseases About DTP DTP vaccine Can prevent diphtheria, tetanus, and pertussis Diphtheria and pertussis Spread from person to person Tetanus Enters the body through cuts or wounds DIPHTHERIA (D) Can lead to difficulty breathing Heart failure, paralysis, or death TETANUS (T) Causes painful stiffening of the muscles Tetanus can lead to serious health problems Including being unable to open the mouth Having trouble swallowing and breathing Or death PERTUSSIS (aP) Also known as “whooping cough” Can cause uncontrollable, violent coughing That makes it hard to breathe, eat, or drink Pertussis can be extremely serious Especially in babies and young children Causes pneumonia, convulsions, brain damage, or death In teens and adults Can cause weight loss Loss of bladder control Passing out, and rib fractures From severe coughing$

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