Ketamine | UPSC

Ketamine mind map
News
Death of Matthew Perry
Date of Death
October 28
Found
In a jacuzzi
At Los Angeles home
Age at Death
54
Cause of Death
Acute effects of ketamine
Drowning
Heart disease
Additional Factors
Effects of buprenorphine
Used for opioid abuse treatment
Autopsy Findings
No alcohol or drugs like cocaine, heroin, fentanyl
Previous Ketamine Use
For anxiety and depression treatment
Stopped more than a week before death
Professional Career
Played Chandler Bing in Friends
Career Span
1994 to 2004
Co-stars
Jennifer Aniston
Courteney Cox
Lisa Kudrow
Matt LeBlanc
David Schwimmer
Personal Life
Struggle with alcohol, opiate addiction
Canadian-born
When
Death Occurred
October 28
News Reported
December 15 - 18
Why
Use of Ketamine
For depression and anxiety treatment
Previously used daily
Overdose
Accidental
Equivalent to general anesthesia dose
What
Ketamine
Sedative
Use in Medicine
For depression treatment
As general anesthesia
FDA Approval
Approved for depression
Mechanism
Acts on brain receptors
Rapid antidepressant action
Effects on neural circuits
Administration
Infusion therapy
Outpatient basis
Matthew Perry's Usage
In context of addiction and mental health
Stopped a week before death
Autopsy Report
Confirms overdose
No other substances found
Where
Los Angeles
Home of Matthew Perry
United States
FDA approval for ketamine treatment
Who
Matthew Perry
Actor
Known for Friends sitcom
Los Angeles County Medical Examiner
Conducted autopsy
FDA
Approved ketamine for depression
How
Ketamine Administration
Infusion therapy
Rapid action
Overdose Mechanism
Unknown method of intake
High quantity in system
Pros/Significance
Treatment for Depression
Fast-acting
Effective in resistant cases
Immediate symptom relief
Used globally
Popular in India
First Centre in Mumbai
Royal Consultancy, Bhiwandi
Patients from various regions
Cons
Risk of Overdose
Accidental overdoses possible
Requires careful monitoring
Addiction Potential
Use in addiction treatment
Risk of misuse
Way Forward
Improved Monitoring
For patients under ketamine therapy
Awareness
About risks and benefits of ketamine
Research
Into long-term effects
On spine formation and behavior correlation

Summary:- Matthew Perry, famed for his role in the sitcom “Friends,” tragically passed away on October 28, 2023, due to the acute effects of a ketamine overdose, which was compounded by drowning and heart disease. Ketamine, a sedative approved by the FDA for treating depression, acts rapidly on brain receptors and is effective in resistant cases. Perry had struggled with addiction and mental health issues, using ketamine to manage anxiety and depression. His death has brought attention to the potential risks and benefits of ketamine, emphasizing the need for careful monitoring and awareness regarding its use. Ketamine therapy is gaining popularity globally, including in India, where it offers immediate relief for depressive symptoms, especially in drug-resistant cases.