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Carbapenem-resistant Acinetobacter baumannii

Carbapenem-resistant Acinetobacter baumannii mind map
Recent News
January 2024
Novel antibiotic class
Roche scientists' discovery
Targets CRAB
Tethered macrocyclic peptides
Inhibit bacterium's wall
Zosurabalpin
Highly effective
Treating CRAB
In vitro and mouse models
Human trials
Starting phase
Results expected
Later in the year
When
Identified recently
Trials beginning
Why
CRAB highly resistant
Mortality rates
40% to 60%
Limited treatment options
Often multi-drug resistant
What
Tethered MCP antibiotics
Block LPS transport
Essential for resistance
Zosurabalpin
Inhibits LptB_{2}FGC complex
Effective against 129 isolates
Where
Global concern
Research based in Basel
Who
Roche Innovation Center
Basel researchers
World Health Organization
Centers for Disease Control and Prevention
How
Screening 45,000 compounds
Identifying potent MCPs
Lab and mouse experiments
Significance
Promising treatment paradigm
Potential for invasive infections
Challenges
High mortality rates
Limited current treatments
Way Forward
Await human trial results
Further development of zosurabalpin

Carbapenem-resistant Acinetobacter baumannii (CRAB) is a highly drug-resistant bacterial pathogen causing nosocomial infections with mortality rates between 40% to 60%. Recently, scientists at Roche have discovered a novel class of tethered macrocyclic peptide (MCP) antibiotics effective against CRAB. These MCPs work by blocking the transport of lipopolysaccharide, crucial for the bacterium’s resistance. The promising antibiotic candidate, zosurabalpin, has shown high efficacy in vitro and in mouse models, with human clinical trials underway. In India, a study highlighted the presence of bla_{OXA-51-like} in all CRAB isolates, with bla_{OXA-23-like} and bla_{NDM-like} being predominant, indicating a potential emerging lineage of carbapenem resistance.

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