Venom-Neutralising Antibody

Venom-Neutralising Antibody mind map
Recent News
Synthetic Human Antibody Developed
Neutralizes Snake Neurotoxins
Across Different Species
Various Geographies
Antibody Name
2554_01_D11
Researchers
Technical University of Denmark
Indian Institute of Science
Scripps Research Institute
Published Studies
Nature Communications
Science Translational Medicine
When
Study Published
February 2023
Why
Combat Snakebites
Reduce Mortality
Universal Antivenom Development
What
Antibody Characteristics
Extensive Cross-Reactivity
Partial Neutralization
Black Mamba Venom
Targets Neurotoxins
Application
Future Envenoming Therapies
Broadly Neutralizing Antibodies
Adapted Approach
Previously Used for HIV, COVID-19
Where
Geographical Impact
Worldwide Relevance
High-Risk Regions
India
Sub-Saharan Africa
Who
Involved Parties
Andreas Hougaard Laustsen-Kiel
Senji Laxme
Kartik Sunagar
Institutions
Technical University of Denmark
Indian Institute of Science
Scripps Research Institute
How
Research Methodology
Screened for Antibodies
Tested on Animal Models
Yeast Cell Surface Display Technique
Toxin Target
Three-Finger Toxin (3FTx)
Conserved Disulphide Core
Significance
Improved Efficacy
15 Times More Effective
Broad Protection
Reduces Need for Animal Antibodies
Potential in Other Therapies
Cancer
Other Toxins
Challenges
Incomplete Neutralization
Certain Venoms
Clinical Trials Required
Production Scalability
Way Forward
Further Testing
More Snake Species
Clinical Trials
Potential Universal Antivenom Creation

Venom-neutralising antibodies represent a groundbreaking advancement in the field of antivenom research. Scientists have developed a synthetic human antibody, 2554_01_D11, capable of neutralizing snake neurotoxins from various species globally. This development, led by researchers from the Technical University of Denmark, Indian Institute of Science, and Scripps Research Institute, was published in Nature Communications and Science Translational Medicine. The antibody, adapted from methods used in HIV and COVID-19 research, targets a conserved region in the toxin, showing potential for broad protection against different snake venoms. This innovation is a significant step towards creating a universal antivenom, offering hope for more effective treatments against snakebites, a major health concern in regions like India and sub-Saharan Africa.

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