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R21/Matrix-M Malaria Vaccine

R21/Matrix-M Malaria Vaccine mind map
Recent News
WHO Prequalification
Eligible for UN procurement
Recommended by WHO
Strategic Advisory Group of Experts (SAGE)
Malaria Policy Advisory Group (MPAG)
In October 2023
Why
High burden of malaria
Especially on African children
What
Developed by
University of Oxford
Serum Institute of India
Leveraging Novavax technology
Efficacy
High in children
Reduces symptomatic malaria
Clinical Trials
Phase III
In 4 countries
Burkina Faso, Kenya, Mali, Tanzania
Manufacturing Capacity
Serum Institute of India
100 million doses per annum
Doubling in next two years
Licensing
Ghana, Nigeria, Burkina Faso
Support
European and Developing Countries Clinical Trials Partnership
Wellcome Trust
European Investment Bank
Where
Global rollout
Who
Developers
Jenner Institute, Oxford
Serum Institute of India
Key Individuals
Adrian Hill
Director, Jenner Institute
Adar Poonawalla
CEO, Serum Institute of India
Recipients
Children in malaria-endemic regions
How
Mass production
Affordable cost
Global distribution
Pros
High efficacy
Reducing malaria cases
Affordable
Cost-effective intervention
Safety
Well-tolerated in trials
Impact
Public health improvement
Challenges
Supply and demand challenges
Comparing with RTS,S/AS01 vaccine
Way Forward
Scaling up production
Expanding reach

The R21/Matrix-M malaria vaccine, a collaborative effort between the University of Oxford and the Serum Institute of India, represents a major advancement in malaria prevention. Recently receiving WHO prequalification, it is now one step closer to being widely deployed, particularly in regions with high malaria transmission. The vaccine has shown high efficacy in preventing malaria in children and is expected to play a crucial role in reducing the global burden of the disease. The Serum Institute of India’s commitment to produce 100 million doses annually, with plans to double this figure, underscores the vaccine’s potential for widespread impact. While specific challenges and concerns related to the vaccine are not fully detailed here, the overall significance of R21/Matrix-M in the fight against malaria is clear, with its affordability and efficacy positioning it as a vital tool in global health.

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