IISc Develops 3D Hydrogel to Study TB Research

The Indian Institute of Science (IISc) in Bengaluru has developed a 3D hydrogel culture system to advance tuberculosis (TB) research. This new method, created by the Department of Bioengineering, mimics the lung environment more accurately than traditional 2D culture plates. The hydrogel uses collagen, a key component of lung tissue, allowing for better interaction between immune cells and TB bacteria. This system keeps cells viable for up to three weeks, significantly longer than traditional methods. The research demonstrated the effectiveness of the TB drug pyrazinamide in this model, and RNA analysis confirmed its similarity to human lung cells. This innovation could lead to more accurate TB treatments and has been patented in India.

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